"> Summary of Vitamin D effects
Vitamin D3 Benefits

Emerging data on Vitamin D has led to the following announcements from the leading
 medical institutions in the world

  • June 2007-Canadian Cancer Society recommends all Canadians take daily Vitamin D3 supplements to prevent cancer 

  • Lack of Vitamin D may increase risk of heart disease-American Heart Association

  • Harvard Medical School Sept 2008-Time for more Vitamin D-Incidence of cancer reduced by 77% with Vitamin D supplements 

  • BUPA-UK Dec 2009-Vitamin D shown to reduce risk of cancer 

The number of diseases connected with vitamin D deficiency can be closely compared to the amount of diseases linked to cigarette smoking

Cancer Prevention and Vitamin D (more details)

  • More than 60 epidemiology studies conducted over the last 20 years have shown that Vitamin D deficiency is associated with increased rates of cancer. (8)

  • A placebo controlled study has confirmed these findings. In the study, vitamin D supplements reduced the incidence of cancer by as much as 77% compared to patients who were given placebo (sugar pill).(29)

  • A prospective study in Finland showed that women with the highest levels of vitamin D had an 84% reduction in their risk of developing lung cancer (34)

  • There was a 72% reduction in the incidence of colorectal cancer between groups of patients with the highest and lowest levels (<20ng/ml vis >32ng/ml) of vitamin D.(40)

  • Comparing women with the lowest and highest levels of vitamin D, there was a almost a 70% reduction of the risk of developing breast cancer in those with the highest levels. (43)

  • Men with low levels of vitamin D(below 16ng/ml) were three times more likely to develop prostate cancer and six times more likely to develop aggressive invasive cancer than men with higher levels.(50)

  • Two large long-term studies have shown that adults who have a higher dietary intake of vitamin D (300-400IU/day) have almost half the risk of developing pancreatic cancer than those with less than 150IU/day vitamin D in their diet. (54)

Potential for Vitamin D in Cancer Treatment (more details)

  • Breast cancer patients with low levels of vitamin D and followed for up to eleven years had a 70% greater chance of dying and twice the rate of developing metastasis than did patients with high levels of vitamin D (90)

  • Lung cancer patients diagnosed in the summer and who had the highest dietary intake of vitamin D compared to those who were diagnosed in the winter and had the lowest intake of vitamin D had five year relapse free survival rates of 56% versus 23% respectively. The five-year survival figures for the two groups were 73% versus 30%(59)

  • Colorectal cancer patients with advanced disease and high vitamin D levels have 60% less chance of dying of the condition than patients with low levels. (64)

  • Prostate Cancer Patients with Vitamin D levels in the mid and high range had a 60% and 85% respectively reduced risk of death from the condition compared to patients with low levels of Vitamin D. This is almost a seven fold increase in the risk of death in those with low vis high vitamin D levels. (152)

The Role of Vitamin D in Diabetes (more details)

  • The incidence of diabetes increases the further from the equator one lives which correlates with lower vitamin D levels (102)

  • Infants given vitamin D supplements for the first year of life demonstrated an 80% reduction in the occurrence of diabetes later in life (103)

  • Also children who were found to have rickets and were vitamin D deficient had a four -fold increased risk of developing diabetes later in life. (103)

  • Diabetic patients who receive vitamin D supplements demonstrate slower progression of their disease. (104,105)

The Role of Vitamin D in Multiple Sclerosis (more details)

  • Multiple Sclerosis (MS) is more common in Northern parts of the world which have less sunlight and therefore lower levels of vitamin D. (106)

  • Studies have shown that the risk of MS is decreased by exposure to sunlight in childhood. (107)

  • Epidemiology data suggests that Vitamin D deficiency in the last three months of pregnancy is particularly harmful to the fetus and raises the risk of MS in later life. (111)

  • Nurses who took 400IU per day of Vitamin D as part of a multivitamin demonstrated a 40% reduced risk of developing MS. (115)

  • Professor Ebers of Oxford University has shown that vitamin D interacts with a specific region of a gene, which is known to exert a direct influence on the risk of developing MS. (118)

  • Only 16% of MS patient experienced a relapse when treated with 14,000IU per day of Vitamin D for twelve months compared to 40% of patients treated with only 1000IU.
       (American Academy of Neurology April 2009)

Vitamin D and Bone Health (more details)

  • Adequate Vitamin D levels are essential for maintaining strong bones and preventing Rickets.

  • Older women with low Vitamin D levels suffer a 70% increased risk of hip fractures. (136)

Vitamin D in Dental Health (more details)

  • Children receiving Vitamin D supplements have a lower number of dental cavities. (119-130)

  • There is a strong association between low Vitamin D levels and increased periodontal disease. (132)

  • Elderly patients with low Vitamin D levels have a higher rate of tooth loss than those with high Vitamin D levels. (133)

Vitamin D and Pregnancy 

  • The Canadian Pediatric Society recommends that women who are pregnant or breast feeding should increase their Vitamin D intake to 2000IU per day.

  • This advice is based on the growing body of evidence that increased exposure to Vitamin D during key points of fetal and infant development may offer protection against many diseases, including asthma, osteoporosis, dental cavities and inflammatory bowel disease. (Press Release)

Vitamin D in Upper Respiratory Tract Infections

  • Vitamin D is known to stimulate the production of potent antimicrobial and antiviral peptides. Deficiencies of these peptides in winter when vitamin D levels are low are thought to explain why respiratory tract infections are more common in the winter (141) 

  • Individuals with low levels of Vitamin D are 40% more likely to suffer upper respiratory tract infections. (coughs and colds) (140)

Autism and Vitamin D Deficiency

  • There is substantial evidence that autism may be caused by vitamin D deficiency during pregnancy and early development.

  • Falling levels of vitamin D over the last 20 years match the increase in incidence of autism (159160) which coincides with when the AMA in 1989, first started to advise keeping infants out of the sun. (161)

  • Estrogen stimulates the activation of vitamin D where as testosterone does not. This may explain why autism is four times as common in males compared to females. (162)

  • Autism is much more common in black races living in Northern areas.  The incidence of autism in Ugandans living in Sweden is 15% of births. (163) Deeply pigmented people living in Northern regions are inevitability vitamin D deficient.

  • Vitamin D has been shown to be essential for normal brain development (164)

  • In a rare condition known as Williams Syndrome children have greatly elevated levels of vitamin D. This conditions presents later in life with overfriendliness, heightened sociability and an unusual willingness to initiate social interaction. These are exactly opposite to the signs of Autism. (165)

 Vitamin D and Heart Disease  (more details)

  • The further from the equator, the higher the risk of cardiovascular disease including hypertension, heart failure, myocardial infarction and death from cardiovascular disease. 

  • A strong correlation has been shown between vitamin D deficiency and the risk of heart attacks. (75)

  • Two large prospective studies have shown that patients with low vitamin D levels have a 200% increase in risk of myocardial infarction and death from cardiovascular disease. (8788)

         Vitamin D and Asthma (more details)

  • children taking Vitamin D supplements had a six-fold reduction in the number of asthma attacks compared to those on placebo. (175)

  • The action of steroids on inflammatory cells taken from patients with asthma were enhanced tenfold by the presence of Vitamin D. (174)

  • asthmatic patients with low vitamin D levels do not respond to corticosteroids as well as those with higher vitamin D levels .(173)

  • decreased lung function is shown to correlate with low Vitamin D levels in adult asthmatics. (173)

  • asthamtic children with low Vitamin D levels use more inhaled steroids and experience more hospitalizations than those with higher levels. (171)

  • low levels of Vitamin D are associated with increasing severity of asthma in children(171)

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